Journal
DEPRESSION AND ANXIETY
Volume 23, Issue 2, Pages 90-92Publisher
WILEY-BLACKWELL
DOI: 10.1002/da.20156
Keywords
CART; mutation; depression; anxiety
Categories
Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000165] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA010732] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR00165] Funding Source: Medline
- NIDA NIH HHS [DA00418, DA10732] Funding Source: Medline
Ask authors/readers for more resources
A Leu34PHe mutation in the cocaine- and amphetamine-regulated transcript (CART) gene has been associated with severe early-onset obesity in an affected family. It has been shown that, in a cell culture system, the mutation resulted in altered CART peptide levels, and animal studies suggest that CART is involved in anxiety as well. The availability of the affected family allowed for testing of anxiety and other traits in humans carrying a mutation in CART gene. This study shows that a small group of adolescents with the mutation exhibit higher anxiety and depression scores than control subjects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available