Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 30, Issue 6, Pages 718-729Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2006.06.001
Keywords
brain; MRI; pediatric; development
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002794, Z01MH002794] Funding Source: NIH RePORTER
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Advances in neuroimaging have ushered in a new era of developmental neuroscience. Magnetic resonance imaging (MRI) is particularly well suited for pediatric studies because it does not use ionizing radiation which enables safe longitudinal scans of healthy children. Key findings related to brain anatomical changes during childhood and adolescent are increases in white matter volumes throughout the brain and regionally specific inverted U-shaped trajectories of gray matter volumes. Brain morphometric measures are highly variable across individuals and there is considerable overlap amongst groups of boys versus girls, typically developing versus neuropsychiatric populations, and young versus old. Studies are ongoing to explore the influences of genetic and environmental factors on developmental trajectories. (c) 2006 Published by Elsevier Ltd.
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