Journal
ACTA HISTOCHEMICA
Volume 108, Issue 5, Pages 327-334Publisher
ELSEVIER GMBH
DOI: 10.1016/j.acthis.2006.03.008
Keywords
cancer metastasis; cell adhesion; cell migration; proteases; inflammation; coagulation; angiogenesis; site selection; VEGFR1; pre-metastatic niche
Categories
Ask authors/readers for more resources
This review provides an introduction to fundamentals and new advances in cancer metastasis for general readers. The first segment includes topics such as cell adhesion, cell migration, proteases, inflammation, coagulation and site selection in metastasis. Then follows a discussion of an interesting report by Kaplan et at. [VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438:820-7] that provides evidence for a rote of VEGFR1 + bone marrow cells in preparing pre-metastatic niches in specific organs that host the arrival and growth of metastatic cancer cells. The therapeutic implications of this study are explored. (c) 2006 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available