Journal
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
Volume 62, Issue 3, Pages 165-167Publisher
KARGER
DOI: 10.1159/000093426
Keywords
cryopreservation; intracytoplasmic sperm injection; Klinefelter's syndrome; testicular sperm extraction
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Background: Pregnancy following frozen thawed embryo transfer in a patient with nonmosaic Klinefelter's syndrome is extremely rare. A healthy ongoing pregnancy achieved with frozen thawed embryo transfer in a patient with nonmosaic Klinefelter's syndrome was described. Method: A case report from a tertiary center for assisted reproductive technologies. A 34-year-old man with azoospermia and nonmosaic Klinefelter's syndrome and his 26-year-old wife presented with primary infertility of 8 years' duration. Frozen thawed embryo transfer following intracytoplasmic sperm injection using surgically retrieved spermatozoa was performed. Results: A healthy ongoing pregnancy with a normal 46,XY karyotype was achieved with day 3 frozen thawed embryo transfer. Conclusion: Frozen thawed embryo transfer may be a viable option to achieve pregnancy in patients with Klinefelter's syndrome. Copyright (c) 2006 S. Karger AG, Basel.
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