Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 17, Issue 1-2, Pages 3-19Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856206774879171
Keywords
dendrimer; biomaterials; nanomedicine; drug delivery; polyamidoamine (PAMAM) dendrimer
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL077825] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL-077825] Funding Source: Medline
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Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.
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