Journal
TUBERCULOSIS
Volume 86, Issue 5, Pages 337-348Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2005.09.001
Keywords
review; cavitation; tuberculosis; animal models; rabbit; guinea pig; monkey
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Funding
- NCRR NIH HHS [RR07002] Funding Source: Medline
- NHLBI NIH HHS [1R01 HL71554] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL071554] Funding Source: NIH RePORTER
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Transmission of tuberculosis occurs with the highest frequency from patients with extensive, cavitary, pulmonary disease and positive sputum smear microscopy. In animal models of tuberculosis, the development of caseous necrosis is an important prerequisite for the formation of cavities although the immunological triggers for liquefaction are unknown. We review the relative merits and the information gleaned from the available animal models of pulmonary cavitation. Understanding the host-pathogen interaction important to the formation of cavities may Lead to new strategies to prevent cavitation and thereby, block transmission. (c) 2005 Elsevier Ltd. All rights reserved.
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