Journal
SEMINARS IN IMMUNOLOGY
Volume 18, Issue 3, Pages 159-166Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2006.03.004
Keywords
natural killer cell receptor; MHC; virus; crystal structure
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI047990] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI047990-08, R01 AI047990, AI47990] Funding Source: Medline
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Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC class I molecules or their structural relatives. The latter group includes self-ligands (MICA, RAE-1, H-60), as well as ligands encoded by viruses (UL18, m155, m157). Two distinct families of NK receptors have been identified: the immunoglobulin-like family (KIRs, LIRs) and the C-type lectin-like family (Ly49s, NKG2D, CD94/NKG2). Here we describe the crystal structures of NK receptors that have been determined to date, both in free form and bound to MHC class I or MHC class I-like molecules. (C) 2006 Elsevier Ltd. All rights reserved.
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