Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 28, Issue 4-5, Pages 420-431Publisher
KARGER
DOI: 10.1159/000094168
Keywords
antioxidant regulation; developing brain; oxidative stress; traumatic brain injury
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P20NS030318, P01NS030318, P50NS030318] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS30318] Funding Source: Medline
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High oxygen demand along with the abundance of readily oxidizable substrates yielding productive oxidative metabolism are required for the normal function of the brain. This necessitates the existence of the complex and multicomponent antioxidant system in the brain for protection against oxidative damage. However, during development, individual components of the antioxidant system are not equally expressed and not always sufficient to fulfill their tasks in a coordinated way. As a result, the developing brain may be more vulnerable to oxidative insults than the adult brain. Traumatic brain injury is one of the damaging acute impacts that challenge the brain antioxidant reserves by exposing them to a number of decompartmentalized prooxidant molecules. This review focuses on the sources and assessment of oxidative stress and the link between oxidative stress and cell death pathways in the immature brain after experimental and clinical traumatic brain injury. Copyright (c) 2006 S. Karger AG, Basel.
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