Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 1, Issue 4, Pages 483-495Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/nano.2006.1.4.483
Keywords
microfabrication; nanofabrication; medical devices; drug delivery; biosensors
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Micro- and nanofabrication techniques have revolutionized the pharmaceutical and medical fields as they offer the possibility for highly reproducible mass-fabrication of systems with complex geometries and functionalities, including novel drug delivery systems and bionsensors. The principal micro- and nanofabrication techniques are described, including photolithography, soft lithography, film deposition, etching, bonding, molecular self assembly, electrically induced nanopatteming, rapid prototyping, and electron, X-ray, colloidal monolayer, and focused ion beam lithography. Application of these techniques for the fabrication of drug delivery and biosensing systems including injectable, implantable, transdermal, and mucoadhesive devices is described.
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