Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 28, Issue 4-5, Pages 327-335Publisher
KARGER
DOI: 10.1159/000094158
Keywords
pediatric traumatic brain injury; serum biomarkers; child abuse; neuron-specific enolase; S100B; myelin basic protein
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Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K23HD043843] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000084] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01 RR00084] Funding Source: Medline
- NICHD NIH HHS [K23HD43843-01] Funding Source: Medline
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Inflicted traumatic brain injury (iTBI) involves a combination of mechanical trauma and hypoxemia. Serum biomarker concentrations may provide objective information about their relative importance to the pathophysiology of iTBI. We compared the time course of neuron-specific enolase (NSE), S100B and myelin basic protein after pediatric hypoxic-ischemic brain injury, iTBI and noninflicted TBI (nTBI). The time to reach peak concentrations of all three biomarkers was shorter after nTBI. Initial and peak S100B, initial and peak myelin basic protein and peak NSE concentrations were no different between the three groups. Initial NSE concentration was highest after nTBI. These results suggest that the biochemical response of the brain to iTBI is distinct from the response to nTBI and shares temporal similarities with hypoxic-ischemic brain injury. This may have important implications for the treatment and prognosis of children with iTBI. Copyright (c) 2006 S. Karger AG, Basel.
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