Journal
ANNALS OF MEDICINE
Volume 38, Issue 8, Pages 552-559Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890600995010
Keywords
cardiovascular and metabolic function; cardiovascular disease; central and peripheral clocks; circadian rhythms; chronotherapy; environmental stress
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The molecular circadian clock entrains biological rhythms to a 24-hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecular clock in the pathophysiology of cardiovascular and metabolic disease.
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