Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 28, Issue 4-5, Pages 380-387Publisher
KARGER
DOI: 10.1159/000094164
Keywords
injury forces; large animal models; traumatic brain injury
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Large animal models have been used much less frequently than rodent models to study traumatic brain injury. However, large animal models offer distinct advantages in replicating specific mechanisms, morphology and maturational stages relevant to age-dependent injury responses. This paper reviews how each of these features is relevant in matching a model to a particular scientific question and discusses various scaling strategies, advantages and disadvantages of large animal models for studying traumatic brain injury in infants and children. Progress to date and future directions are outlined. Copyright (c) 2006 S. Karger AG, Basel.
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