Journal
JOURNAL OF NATURAL MEDICINES
Volume 60, Issue 3, Pages 185-190Publisher
SPRINGER TOKYO
DOI: 10.1007/s11418-005-0028-9
Keywords
Penicillium simplicissimum; penicillide; secopenicillide A; secopenicillide B; purpactin A; antifungal activity
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Two new penicillide derivatives, secopenicilides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.
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