Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 28, Issue 3, Pages 171-185Publisher
KARGER
DOI: 10.1159/000091915
Keywords
serotonin; embryonic development; morphogenesis; asymmetry; craniofacial development
Categories
Funding
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE013314] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [U54MH066418] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R21DA018103] Funding Source: NIH RePORTER
- NCI NIH HHS [CO6RR11244] Funding Source: Medline
- NIDA NIH HHS [R21 DA018103-01] Funding Source: Medline
- NIDCR NIH HHS [DE13314-05] Funding Source: Medline
- NIGMS NIH HHS [1-R01-GM-06227] Funding Source: Medline
- NIMH NIH HHS [U54 MH66418] Funding Source: Medline
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Serotonin is a clinically important neurotransmitter regulating diverse aspects of cognitive function, sleep, mood, and appetite. Increasingly, it is becoming appreciated that serotonin signaling among non-neuronal cells is a novel patterning mechanism existing throughout diverse phyla. Here, we review the evidence implicating serotonergic signaling in embryonic morphogenesis, including gastrulation, craniofacial and bone patterning, and the generation of left-right asymmetry. We propose two models suggesting movement of neurotransmitter molecules as a novel mechanism for how bioelectrical events may couple to downstream signaling cascades and gene activation networks. The discovery of serotonin-dependent patterning events occurring long before the development of the nervous system opens exciting new avenues for future research in evolutionary, developmental, and clinical biology. Copyright (c) 2006 S. Karger AG, Basel.
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