Journal
INTERNATIONAL JOURNAL OF BIOMEDICAL IMAGING
Volume 2006, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/IJBI/2006/79862
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Funding
- federal [NINDS RO1 NS35069, NIA RO1 AG16714, NINDS RO1 NS02138]
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In brain mapping studies of sensory, cognitive, and motor operations, specific waveforms of dynamic neural activity are predicted based on theoretical models of human information processing. For example in event-related functional MRI (fMRI), the general linear model (GLM) is employed in mass-univariate analyses to identify the regions whose dynamic activity closely matches the expected waveforms. By comparison multivariate analyses based on PCA or ICA provide greater flexibility in detecting spatiotemporal properties of experimental data that may strongly support alternative neuroscientific explanations. We investigated conjoint multivariate and mass-univariate analyses that combine the capabilities to (1) verify activation of neural machinery we already understand and (2) discover reliable signatures of new neural machinery. We examined combinations of GLM and PCA that recover latent neural signals (waveforms and footprints) with greater accuracy than either method alone. Comparative results are illustrated with analyses of real fMRI data, adding to Monte Carlo simulation support. Copyright (C) 2006 J. R. Moeller and C. G. Habeck.
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