Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 28, Issue 4-5, Pages 396-409Publisher
KARGER
DOI: 10.1159/000094166
Keywords
traumatic brain injury; immature brain; cognitive function; delayed cell loss
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050159] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS050159, R21NS41246] Funding Source: Medline
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The immature brain may be particularly vulnerable to injury during critical periods of development. To address the biologic basis for this vulnerability, mice were subjected to traumatic brain injury at postnatal day 21, a time point that approximates that of the toddler-aged child. After motor and cognitive testing at either 2 weeks (juveniles) or 3 months (adults) after injury, animals were euthanized and the brains prepared for quantitative histologic assessment. Brain-injured mice exhibited hyperactivity and age-dependent anxiolysis. Cortical lesion volume and subcortical neuronal loss were greater in brain-injured adults than in juveniles. Importantly, cognitive decline was delayed in onset and coincided with loss of neurons in the hippocampus. Our findings demonstrate that trauma to the developing brain results in a prolonged period of pathogenesis in both cortical and subcortical structures. Behavioral changes are a likely consequence of regional-specific neuronal degeneration. Copyright (c) 2006 S. Karger AG, Basel.
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