Journal
ADVANCES IN CHRONIC KIDNEY DISEASE
Volume 13, Issue 1, Pages 47-55Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2005.11.001
Keywords
cyclosporine nephrotoxicity; tacrolimus nephrotoxicity; kidney transplantation; chronic kidney disease; transplant failure
Categories
Ask authors/readers for more resources
Calcineurin inhibitors, cyclosporine and tacrolimus, have improved allograft survival in solid organ transplantation. Indeed, they have reduced the incidence of acute rejection episodes of cadaveric allograft recipients. Although marked progression has been made in initial survival rates, long-term kidney graft survival has yet to show such encouraging results. Chronic allograft dysfunction is the major hindrance to long-term graft survival and many components contribute to this entity, both immunologic and nonimmunologic. Chronic calcineurin nephrotoxicity is a major factor in chronic allograft dysfunction. This review will highlight the current understanding and management of calcineurin nephrotoxicity in kidney transplantation. (c) 2006 by the National Kidney Foundation, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available