Journal
CHROMOSOMA
Volume 115, Issue 3, Pages 175-194Publisher
SPRINGER
DOI: 10.1007/s00412-006-0055-7
Keywords
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM025326, R37GM025326] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM025326, GM44794, GM25326] Funding Source: Medline
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Meiotic recombination proceeds in biochemical complexes that are physically associated with underlying chromosome structural axes. In this study, we discuss the organizational basis for these axes, the timing and nature of recombinosome/axis organization with respect to the prophase program of DNA and to structural changes, and the possible significance of axis organization. Furthermore, we discuss implications and extensions of our recently proposed mechanical model for chiasma formation. Finally, we give a broader consideration to past and present models for the role of the synaptonemal complex.
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