Topical photodynamic therapy for non-cancerous skin conditions

Topical photodynamic therapy (PDT) is a non-invasive therapeutic modality which is developing increasing use in dermatology. It is a well established treatment for pre-malignant and malignant skin tumours and over recent years there has also been encouraging evidence for its use in treating benign cutaneous disorders. We review the literature and clinical trials utilising topical PDT for non-cancerous skin conditions. Recalcitrant warts, acne vulgaris and psoriasis have so far been studied in most detail. At present, photosensitisers, light sources and treatment parameters of PDT vary in different clinical trials even for the same conditions. Optimum parameters for PDT need to be established and comparison randomised studies are required to clarify whether PDT for benign dermatoses is significantly superior to existing therapeutic modalities. (C) 2006 Elsevier B.V. All rights reserved.