Journal
PHYSIOLOGY
Volume 21, Issue -, Pages 181-188Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00058.2005
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Wnt growth factors function via Frizzled receptors to affect cellular proliferation, differentiation, apoptosis, and migration. Wnt/Frizzled signaling is now linked to human hereditary disorders with retinal vascular defects, implicating Wnts as angiogenic factors. Here, we discuss Wnts and a novel Frizzled ligand, Norrin, in physiological and pathological angiogenesis.
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