Journal
JOURNAL OF LIPOSOME RESEARCH
Volume 16, Issue 1, Pages 17-25Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08982100500528594
Keywords
liposomes; flavonoids; lyophilization
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Liposomes composed of egg-phosphatidylcholine (EPC) incorporating quercetin (QR) were prepared by the thin-film hydration method (TFHM) and the monophase solution method (MSM). A rapid and slow freeze-drying process was applied for both laboratory and industrial scales. The purpose of this study was to compare the two methods of liposome preparation, and further determine whether the lyophilization process affects the liposome physicochemical characteristics (size, polydispersity index, and zeta-potential) and incorporation of quercetin.
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