The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny

Fetal hematopoietic development occurs through the successive expansion and differentiation of hematopoietic stem cells in distinct anatomic sites. The temporal pattern of fetal hernatopoietic ontogeny suggests a coordinated developmental sequence whereby the preceding organ sustains the basic, immediate hematopoietic needs of the embryo allowing time for the development of niches within the subsequent organ with more complex supportive functions. We examine the hypothesis that there is a period of stromal genesis and circulating mesenchymal precursor cells, which gives rise to specialized niches within each of the definitive fetal hernatopoietic organs, and these niches regulate hernatopoietic stem cells fate determination. This article reviews fetal hernatopoietic and stromal development and the current understanding of the development, composition, and regulation of the fetal stem cell niche.