Journal
NEURON GLIA BIOLOGY
Volume 2, Issue -, Pages 165-174Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1740925X06000275
Keywords
contactin associated protein; Caspr; paranode; myelin; sciatic nerve; axonal transport
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063074] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS043474, R01NS050356] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM063074, R01 GM063074-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS043474, R01 NS050356, R01 NS043474-04] Funding Source: Medline
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Mitochondria and other membranous organelles are frequently enriched in the nodes and paranodes of peripheral myelinated axons, particularly of large caliber axons. The physiological role(s) of this organelle enrichment and the rheologic factors that regulate it are not well understood. Previous studies indicate that axonal transport of organelles across the nodallparanodal region is regulated locally. In this study, we have examined the ultrastructure of myelinated axons in the sciatic nerves of mice deficient in contactin-associated protein (Caspr), an integral junctional component. These mice, which lack the normal septate-like junctions that promote attachment of the glial (paranodal) loops to the axon, contain aberrant mitochondria in their nodallparanodal regions. Typically, these mitochondria are large, swollen and occupy prominent varicosities of the nodal axolemma. In contrast, mitochondria outside the nodallparanodal regions of the myelinated axons appear normal. These findings suggest that paranodal junctions regulate mitochondrial transport and function in the axoplasm of the nodal/paranodal region of myelinated axons of peripheral nerves. They further indicate that paranodal junctions might have a role, either direct or indirect, in the local regulation of energy metabolism in the nodal region.
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