Journal
COMMUNITY GENETICS
Volume 9, Issue 1, Pages 55-61Publisher
KARGER
DOI: 10.1159/000090694
Keywords
biobank; complex diseases; genetic epidemiology; genotype-phenotype relationship; population-based sampling; relative risk
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Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. Results: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. Conclusion: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition. Copyright (C) 2006 S. Karger AG, Basel.
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