4.5 Review

Does nitric oxide regulate skeletal muscle glucose uptake during exercise?

Journal

EXERCISE AND SPORT SCIENCES REVIEWS
Volume 34, Issue 1, Pages 36-41

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200601000-00008

Keywords

nitric oxide synthase; AMP-activated protein kinase; calcium; peroxynitrite; contraction

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Although rodent studies are contradictory, there is accumulating evidence in humans suggesting that nitric oxide (NO) is involved in skeletal muscle glucose uptake during exercise. This brief review discusses this controversial area, including potential upstream regulators of skeletal muscle NO synthase (NOS).

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