Journal
FEMS MICROBIOLOGY REVIEWS
Volume 30, Issue 1, Pages 3-16Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2005.004.x
Keywords
riboswitch; RNA sensor; heat shock; chaperones; virulence
Categories
Ask authors/readers for more resources
Temperature is an important parameter that free-living cells monitor constantly. The expression of heat-shock, cold-shock and some virulence genes is coordinated in response to temperature changes. Apart from protein-mediated transcriptional control mechanisms, translational control by RNA thermometers is a widely used regulatory strategy. RNA thermometers are complex RNA structures that change their conformation in response to temperature. Most, but not all, RNA thermometers are located in the 5'-untranslated region and mask ribosome-binding sites by base pairing at low temperatures. Melting of the structure at increasing temperature permits ribosome access and translation initiation. Different cisacting RNA thermometers and a trans-acting thermometer will be presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available