Journal
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
Volume 26, Issue 5-6, Pages 473-485Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10799890600950545
Keywords
signal transduction; adrenaline; GPCR; receptor tyrosine kinase; transmembrane unit; second messenger
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Multifunctional transmembrane-building blocks with recognition sites for adrenaline on one end and the reaction partners for an S(N)2 reaction on the opposite end have been embedded in DPPC-liposomes. These doped vesicles can be quantitatively reduced at their disulfide head groups by externally added reducing agents; their composition and chemical processes taking place within can be monitored by NMR spectroscopy andwith limitations-by UV/Vis spectroscopy. Attempted release of thiopyridine as a second messenger into the interior of the liposome on external adrenaline addition could not be proven unambiguously because the detection system does not fulfill the necessary rigorous specificity and sensitivity requirements.
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