Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Volume 7, Issue 3, Pages 158-161Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622970600554711
Keywords
association; bipolar disorder; glycogen synthase kinase-3 beta gene; lithium response
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A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3 beta (GSK-3 beta) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response.
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