Journal
JOURNAL OF ENDOTOXIN RESEARCH
Volume 12, Issue 4, Pages 251-256Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1179/096805106X118771
Keywords
caspase-1; innate immunity; interleukin-1 beta; macrophages; NACHT-LRR (NLR)
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Funding
- NIAID NIH HHS [T32 AI-0075 17] Funding Source: Medline
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The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases. Mutations in the NALP3/CIAS1/cryopyrin gene, a member of the NLR family, are linked to three auto-inflammatory disorders: Muckle-Wells syndrome, familial cold auto-inflammatory syndrome and neonatal-onset multisystem inflammatory disease. NALP3 along with the adaptor molecule ASC activates caspase-1 in response to a wide variety of stimuli. Here we review recent findings on the biology of NALP3 suggesting that it has functions beyond that of pathogen recognition.
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