Journal
AUDIOLOGY AND NEURO-OTOLOGY
Volume 11, Issue 5, Pages 318-330Publisher
KARGER
DOI: 10.1159/000095818
Keywords
hearing loss; audiometric pattern; cisplatin; radiotherapy; head and neck cancer
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This study describes audiometric patterns of ototoxicity in a consecutive series of patients uniformly treated with intra-arterial high-dose cisplatin chemoirradiation for advanced cancer of the head and neck. Air conduction thresholds were measured from 0.125 to 16 kHz and bone conduction thresholds were measured from 0.5 to 4 kHz. The overall audiometric pattern was characterized by maximum threshold shifts after the 2nd cisplatin infusion and a maximum total threshold shift at 8 kHz, irrespective of gender, age, pretreatment sensorineural hearing loss ( SNHL) or subjective complaints during therapy. A hearing deterioration gradient was observed from ( ultra-) high to low frequencies, worse with increasing pre-existent SNHL and with increasing cumulative dose of cisplatin chemoradiation. Cisplatin chemoradiation-induced hearing loss seemed to reach a plateau at higher levels ( 75-80 dB HL) for frequencies above 8 kHz compared to frequencies up to 8 kHz ( 45-60 dB HL). Recovery of SNHL was found after therapy in 27 ears characterized by extensive hearing loss at frequencies 1, 2 and 4 kHz. Copyright (C) 2006 S. Karger AG, Basel.
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