Journal
CANCER RESEARCH
Volume 71, Issue 1, Pages 3-7Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-10-2483
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Funding
- National Institutes of Health [R01-CA118750, T32-AR007422]
- California Institute for Regenerative Medicine [RN1-00529-1]
- American Cancer Society [RSG 07-084-01-MGO]
- Susan G. Komen Foundation
- NATIONAL CANCER INSTITUTE [R01CA118750] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [T32AR007422] Funding Source: NIH RePORTER
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The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets. Cancer Res; 71(1); 3-7. (C) 2011 AACR.
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