Journal
JOURNAL OF IMMUNOLOGY
Volume 176, Issue 11, Pages 6405-6410Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.176.11.6405
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Funding
- NATIONAL CANCER INSTITUTE [T32CA101968] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007971] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI054488] Funding Source: NIH RePORTER
- NCI NIH HHS [CA101968] Funding Source: Medline
- NHLBI NIH HHS [HL07971] Funding Source: Medline
- NIAID NIH HHS [AI54488] Funding Source: Medline
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The BLyS family of ligands and receptors governs B cell homeostasis by controlling survival, differentiation, and lifespan. This family consists of multiple receptors and ligands, allowing independent regulation of different B cell subsets by varying the combination and levels of receptors expressed. Multiple downstream signaling pathways are implicated in these activities, reflecting this receptor complexity as well as cross-talk with other B cell signaling systems. BLyS levels are associated with multiple forms of humoral autoimmunity and can modulate tolerogenic elimination at the transitional checkpoint. BLyS responsiveness thus balances peripheral selection against cell numbers, providing an elastic system that varies selective stringency based on homeostatic demands.
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