Journal
MOVEMENT DISORDERS
Volume 21, Issue 10, Pages 1688-1692Publisher
WILEY-LISS
DOI: 10.1002/mds.21009
Keywords
chemical exposures; pesticides; Parkinson's disease; case-control study; sex differences
Categories
Funding
- NIAMS NIH HHS [R01 AR30582] Funding Source: Medline
- NIEHS NIH HHS [R01 ES10751] Funding Source: Medline
- NINDS NIH HHS [R01 NS33978] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR030582] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES010751] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS033978] Funding Source: NIH RePORTER
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The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women. (C) 2006 Movement Disorder Society.
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