Journal
NEUROSCIENCE RESEARCH
Volume 56, Issue 1, Pages 124-127Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2006.05.008
Keywords
vesicular glutamate transporter; oxytocin; magnocellular neuron; osmotic challenge; paraventricular nucleus; supraoptic nucleus; neurohypophysis
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A second vesicular glutamate transporter (VGLUT2) is detected in magnocellular neurons in the rat hypothalamus. The present study revealed what phenotype of neurons express VGLUT2 mRNA by the histological method. We found that most vasopressin (VP) neurons and several oxytocin (OT) neurons express VGLUT2 mRNA. VGLUT2 gene expression in VP and OT neurons is enhanced with osmotic challenges. In the neurohypophysis, VGLUT2-staining in OT terminals was reduced with osmotic stimulation. These results indicate that VGLUT2 is principally expressed in VP neurons and also in some OT neurons and that VGLUT2 in VP and OT neurons is involved in osmotic regulation. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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