Journal
ANALYTICAL METHODS
Volume 7, Issue 6, Pages 2529-2536Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ay02944e
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Funding
- EU
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An electrochemical sensor for the sensitive and selective detection of cysteine is proposed based on a gold nanoparticle (AuNP)-iron(III) phthalocyanine (FePc) modified graphite paste electrode. The sensor was characterised using scanning electron microscopy (SEM/EDX), transmission electron microscopy (TEM), cyclic voltammetry and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry studies demonstrated that the electrochemical behaviour of cysteine at the AuNP-FePc modified graphite paste electrode is considerably improved compared to both the blank (unmodified) and FePc-modified graphite paste electrodes. The enhancement of the anodic redox signal for cysteine was due to a catalytic effect of gold nanoparticles which was investigated using three different graphite paste electrodes -0.02, 0.055 and 0.11 wt% Au nanoparticles, each with a fixed quantity of FePc (5 wt%). The sensor fabricated using 0.055 wt% AuNPs exhibited optimum sensitivity as examined via differential pulse voltammetry measurements with an analytical range of 50-1000 mu M and a LOD of 0.27 mu M. The sensor was utilised for the determination of cysteine in pharmaceutical preparations.
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