Journal
OSTEOPOROSIS INTERNATIONAL
Volume 17, Issue 1, Pages 119-124Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s00198-005-1930-4
Keywords
body mass index; bone mineral density; genetic correlation
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Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K01AR002170] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060402] Funding Source: NIH RePORTER
- NIAMS NIH HHS [K01 AR02170-01A2] Funding Source: Medline
- NIGMS NIH HHS [R01 GM60402] Funding Source: Medline
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The purpose of the present study was to evaluate the magnitude of genetic determination of spine and hip bone mineral density (BMD) and body mass index (BMI), and to explore the genetic, environmental, and phenotypic correlations among the above phenotypes in Chinese Han ethnicity. The sample was composed of at least 217 complete nuclear families in Chinese Han ethnicity. BMD at the spine and hip was measured using a dual-energy X-ray absorptiometry scanner. The heritability ( h (2)) of BMI and BMD at the spine and hip, the genetic correlation (rho(G)) and environmental correlation (rho(E)) among the three phenotypes were evaluated via variance analysis, with age, sex, and age-by-sex interaction as covariates. The phenotypic correlation (rho(P)) and the bivariate heritability rho G(2) were also calculated. The heritability for BMD and BMI was similar to 0.70 and similar to 0.50, respectively ( p< 0.0001). The common environment shared by household members ( household effect) is significant for BMI variation ( p= 0.0004). Significant genetic, environmental, and phenotypic correlation was observed. The rho G(2) values were 0.13 for BMI/ spine BMD, 0.18 for BMI/ hip BMD, and 0.58 for the spine BMD/ hip BMD. While BMD at the spine and hip have significant genetic determination, BMI is more likely to be affected by environmental factors than BMD. In addition, BMD at the spine and hip shares more genetic effect ( pleiotropy) than BMI and BMD do in Chinese Han ethnicity, though the effects are significant for both.
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