Journal
CANCER RESEARCH
Volume 70, Issue 23, Pages 9581-9590Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-10-1379
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Funding
- NIH [5 P50 CA093459-05-DRP14]
- Center for Targeted Therapy of MD Anderson Cancer Center
- Miriam and Sheldon Adelson Medical Research Foundation (AMRF)
- M. D. Anderson Cancer Center
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CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion. Cancer Res; 70(23); 9581-90. (C) 2010 AACR.
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