Journal
NUCLEIC ACIDS RESEARCH
Volume 34, Issue 13, Pages 3609-3614Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkl232
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Funding
- FIC NIH HHS [R03 TW001068, 1R03 TW1068] Funding Source: Medline
- NIGMS NIH HHS [R01 GM022939, GM22939] Funding Source: Medline
- FOGARTY INTERNATIONAL CENTER [R03TW001068] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM022939] Funding Source: NIH RePORTER
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Results from optical melting studies of Watson-Crick complementary heteroduplexes formed between 2'-O-methyl RNA and RNA oligonucleotides are used to determine nearest neighbor thermodynamic parameters for predicting the stabilities of such duplexes. The results are consistent with the physical model assumed by the individual nearest neighbor-hydrogen bonding model, which contains terms for helix initiation, base pair stacking and base pair composition. The sequence dependence is similar to that for Watson-Crick complementary RNA/RNA duplexes, which suggests that the sequence dependence may also be similar to that for other backbones that favor A-form RNA conformations.
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