4.8 Review

Cbl-b and Itch: Key Regulators of Peripheral T-cell Tolerance

Journal

CANCER RESEARCH
Volume 70, Issue 8, Pages 3009-3012

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-09-4076

Keywords

-

Categories

Funding

  1. NIH/National Cancer Institute [RCA146576A]

Ask authors/readers for more resources

E3 ligases Cbl-b and Itch have emerged as dominant tolerogenic regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-beta (TGF-beta) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer. Cancer Res; 70(8); 3009-12. (C) 2010 AACR.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available