Journal
CANCER RESEARCH
Volume 70, Issue 8, Pages 3009-3012Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-09-4076
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Funding
- NIH/National Cancer Institute [RCA146576A]
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E3 ligases Cbl-b and Itch have emerged as dominant tolerogenic regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-beta (TGF-beta) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer. Cancer Res; 70(8); 3009-12. (C) 2010 AACR.
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