Journal
CANCER RESEARCH
Volume 70, Issue 6, Pages 2158-2164Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-09-3458
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Funding
- Howard Hughes Medical Institute
- NIH [RO1 CA207186, RO1 CA57683, K08 DK080175]
- T32 Institutional Ruth L. Kirschstein National Research Service Award
- MGH
- Burroughs Wellcome Fund
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In a genome-wide screen of 684 cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reconstituting PARD3 expression in both cell types restores tight junctions and retards contact-dependent proliferation. Searching specifically for small intragenic microdeletions using high-resolution genomic arrays may be complementary to other genomic deletion screens and resequencing efforts in identifying new tumor suppressor genes. Cancer Res; 70(6); 2158-64. (C) 2010 AACR.
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