Journal
CANCER RESEARCH
Volume 70, Issue 7, Pages 2571-2574Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-09-2536
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Funding
- Ovarian Cancer Research Fund
- Laura and John Arnold Foundation
- M.D. Anderson Cancer Center [P50 CA083639]
- NIH [CA110793, CA109298]
- DOD [OC093146]
- T32 Training Grant [CA101642]
- Gynecologic Cancer Foundation
- Zarrow Foundation
- Betty Ann Asche Murray Distinguished Professorship
- Blanton-Davis Ovarian Cancer Research Program
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The dynamic properties of RNA interference (RNAi) in cancer biology have led investigators to pursue with significant interest its role in tumorigenesis and cancer therapy. We recently reported that decreased expression of key RNAi enzymes, Dicer and Drosha, in epithelial ovarian cancers was associated with poor clinical outcome in patients. Dicer expression was also functionally relevant in that targeted silencing was limited with RNAi fragments that require Dicer function compared with those that do not. Together, this and other studies suggest that RNAi machinery expression may affect key pathways in tumorigenesis and cancer biology. Understanding alterations in the functional RNAi machinery is of fundamental importance as we strive to develop novel therapies using RNAi strategies. Cancer Res; 70(7); 2571-4. (C) 2010 AACR.
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