Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 545, Issue 1, Pages 22-28Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2006.06.027
Keywords
nuclear factor-kappaB; neurodegeneration; cell death; amyloid beta; c-Rel; p65
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The nuclear transcription factors kappa B (NF-kappa B) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-kappa B can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-kappa B in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-kappa B in brain dysfunctions arises from the identification of diverse NF-kappa B complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-kappa B complexes for the treatment of neurodegenerative disorders and memory dysfunctions. (c) 2006 Elsevier B.V. All rights reserved.
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