Journal
BIOPHYSICAL JOURNAL
Volume 90, Issue 2, Pages 413-422Publisher
BIOPHYSICAL SOCIETY
DOI: 10.1529/biophysj.105.069765
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The extent and dynamics of actin polymerization in solution are calculated as functions of the. lament severing rate, using a simple model of in vitro polymerization. The model is solved by both analytic theory and stochastic-growth simulation. The results show that severing essentially always enhances actin polymerization by freeing up barbed ends, if barbed-end cappers are present. Severing has much weaker effects if only pointed-end cappers are present. In the early stages of polymerization, the polymerized-actin concentration grows exponentially as a function of time. The exponential growth rate is given in terms of the severing rate, and the latter is given in terms of the maximum slope in a polymerization time course. Severing and branching are found to act synergistically.
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