Journal
HORMONE RESEARCH
Volume 65, Issue 6, Pages 267-268Publisher
KARGER
DOI: 10.1159/000092513
Keywords
hypothyroidism; nerve deafness; DEP-1/CD148 antibodies
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Male, dizygotic twins were diagnosed with sensori-neural deafness at ages 5 and 21 months and later developed hypothyroidism at ages 24 and 28 months, respectively. Analysis for anti-DEP-1/CD148 autoantibodies described in Cogan syndrome proved positive. As these antibodies are directed against endothelial cells as well as sensory epithelial cells the children need long-term monitoring for associated complications.
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