4.4 Article

A sigma(28)-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176

Journal

INFECTION AND IMMUNITY
Volume 74, Issue 1, Pages 769-772

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.1.769-772.2006

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Funding

  1. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI043559] Funding Source: NIH RePORTER
  2. NIAID NIH HHS [R01 AI 043559, R01 AI043559] Funding Source: Medline

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A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.

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