Journal
ANNALS OF NEUROLOGY
Volume 59, Issue 1, Pages 200-203Publisher
WILEY-LISS
DOI: 10.1002/ana.20707
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Funding
- NIA NIH HHS [U01 AG 06786, P50 AG 16574] Funding Source: Medline
- ASPE HHS [R01 AE 11378] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P50AG016574, U01AG006786] Funding Source: NIH RePORTER
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Objective To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results. Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP.
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