4.4 Article

Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA

Journal

JOURNAL OF BACTERIOLOGY
Volume 188, Issue 1, Pages 339-342

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.188.1.339-342.2006

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Undirected mismatch repair initiated by the incorporation of the base analog 2-aminopurine kills DNA-methylation-deficient Escherichia coli dam cells by DNA double-strand breakage. Subsequently, the chromosomal DNA is totally degraded, resulting in DNA-free cells.

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