Journal
DRUG METABOLISM REVIEWS
Volume 38, Issue 1-2, Pages 197-207Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03602530600570057
Keywords
liver; sex difference; cytochrome P450; growth hormone; gene regulation; rat
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Metabolism of steroids and drugs in rodents is sexually differentiated. The reason for this turned out to be the sexually differentiated growth hormone (GH) secretory pattern regulating the expression of a number of hepatic cytochrome P-450 genes. Although not fully resolved, it is clear that several signaling pathways and transcription factors are involved in mediating the effects of GH. It may be argued that such a well-controlled physiological system should have an important biological role and we speculate that the demands of a robust hepatic steroid metabolism during pregnancy has led to the development of this sexually differentiated hypothalmno-pituitary-liver axis.
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