Journal
INFECTION AND IMMUNITY
Volume 74, Issue 1, Pages 773-776Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.1.773-776.2006
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Funding
- Medical Research Council [G0400786] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G0400786] Funding Source: UKRI
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CD8(+) T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8(+) T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8(+) T cells is strictly dependent upon the presence of cognate antigen.
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