Journal
DRUG METABOLISM REVIEWS
Volume 38, Issue 4, Pages 615-626Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03602530600959417
Keywords
furan; carcinogenesis; toxicity; metabolism; glutathione conjugates; stable isotope methods; alpha,beta-unsaturated aldehyde
Categories
Funding
- NIEHS NIH HHS [ES-10577, ES-10956] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [T32ES010956, R01ES010577] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The industrial and environmental chemical, furan, is a liver toxicant and carcinogen in laboratory animals. It has been classified as a possible human carcinogen. The mechanism of tumor induction is unknown. However, toxicity is initiated by cytochrome P450 catalyzed oxidation of furan to an alpha,beta-unsaturated dialdehyde, cis-2-butene-1,4-dial This metabolite reacts readily with protein and DNA nucleophiles and is a bacterial mutagen in Ames assay strain TA104. Metabolism studies indicate that this reactive metabolite is formed in vivo. It is also an intermediate leading to other metabolites whose role in furan-derived toxicities has yet to be explored.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available